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Understanding the constellation of changes unique to H3.3 mutants should allow identification of additional subtypes and driver genes.
All ten showed the constellation of changes required for the histologic diagnosis of ACD/MPV.
In isolation, these changes are seldom specific enough to diagnose HIVE, but when observed in combination with other features they contribute to a highly characteristic constellation of changes.
DOI: http://dx.doi.org/10.7554/eLife.01913.006 Analysis of peripheral blood from TSC-KO mice revealed a constellation of changes consistent with macrocytic anemia.
The multiple effects of acrolein on lung function indicate that there are a constellation of changes to lung function measurements consistent with the potential for adverse effects in humans.
While a constellation of changes is likely necessary to stimulate and sustain compulsive drug use, resistance to change in one or a few arenas might be sufficient to confer a significant protective advantage.
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New constellations of change makers were affecting systems on the scale of the whole, often by linking innovative prototypes with change makers in the media, ministries, business, and civil society.
Illness in the intensive care unit is defined not by pathologic changes in a particular tissue or by structural changes in a specific organ, but by a constellation of quantifiable changes in physiological and biochemical measures.
The constellation of metabolic changes in cancer cells includes aerobic glycolysis first described by Warburg, changes in TCA cycle function, activation of the pentose phosphate pathway and the "addiction" to glutamine.
But my constellation of little changes seemed just evidence, really, that with continuous effort, I could change the way my mind worked.
This constellation of concepts changes with Kant.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com