Sentence examples for constellation of alterations from inspiring English sources

While increased oxidative stress resistance alone is unlikely to affect lifespan, it might be part of a constellation of alterations that together allow the animal to live longer by increasing its ability to repair or prevent damage caused by different types of stressors.

This constellation of alveolar alterations has profound consequences for pulmonary gas exchange and pulmonary mechanics.

The prognosis, prediction and treatment of breast cancer are complicated by the diverse constellation of causative alterations within multiple biological pathways that lead to this heterogeneous disease.

Obesity is associated with a constellation of metabolic alterations that are risk factors for coronary heart disease, including diabetes, dyslipidemia, and nonalcoholic fatty liver disease (1).

Array Comparative Genomic Hybridization (array CGH) is a powerful whole genome profiling technology capable of detecting both DNA copy gain and loss that has the potential for unbiased classification of tumor specimens based upon the constellation of genomic alterations that they possess.

AO is distinguished from other brain tumors by a unique constellation of molecular genetic alterations, including the coincident loss of chromosomal arms 1p and 19q in 50 70% of tumors (Gregory et al. 1998).

Anaplastic oligodendrogliomas further share a constellation of molecular genetic alterations including coincident loss of chromosomal arms 1p and 19q in 50 70% of tumors [ 5].

In this setting, AOs are also distinguished by a unique constellation of molecular genetic alterations that can distinguish OD from astrocytomas and other glioma subtypes.

The future of cancer management will likely be governed by partitioning tumors into categories or classes based on their constellation of mutations, structural alterations and epigenetic states that control oncogenic pathways.

The specific constellation of DNA copy number alterations within a tumor or precursor lesion may provide biological insight and prognostic/predictive value.

Nevertheless, simple enumeration of CTCs is inadequate because cancer is a constellation of diseases with various pathologic alterations that might cause prognosis.