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Time course analysis revealed that, in contrast to zVAD-fmk which constantly inhibited the processing of endogenous caspase substrates, zAsp-CH2-DCB inhibited substrate processing only for the first few hours after its addition to the culture medium.
Oxamate inhibited the catalytic reactions of FNLDH competitively with pyruvate, and the PALDH reaction in a mixed manner at pH 7.0, but markedly enhanced the reactions of the two enzymes at low concentration through canceling of the apparent homotropic cooperativity at pH 8.0, although it constantly inhibited the ECLDH reaction.
She was often hampered by her own ideals, her lack of pragmatism constantly inhibited her ability to make good decisions, had a quick temper with anything she perceived unfair, and she did not understand anything about the darker hues of human nature.
If a protein is constantly inhibited (in an experiment), we restrain the state of its corresponding variable in the model to be always in either 0 (lower than control) or 1 (control state).
CDK11p58 inhibited the promoter activity of VEGF regulation at the transcriptional level and constantly inhibited angiogenesis-related protein expression in a kinase dependent manner.
As mentioned above, neurophysiological data implicate that in Parkinson's disease the superior colliculus is constantly inhibited by the basal ganglia, while for adequate visual guidance, intermittent disinhibition of the superior colliculus would be required.
Similar(53)
A gradual increase in dehydrogenase activity was observed as the glycerol concentration increased, although methanol inhibited dehydrogenase activity constantly by approximately 60% as compared to that in the absence of methanol (data not shown).
Indeed, the kinase constantly activated mutant T370D significantly inhibited the VEGF promoter activity compared with the kinase-dead mutant T370A and D224N.
Live cell microscopy showed that these actin-filled protrusions were constantly "tapping" neighboring cells across the small space between contact inhibited cells.
Increased autophagic flux in the early phase of 2DG treatment was eventually inhibited by the expanded time of 2DG treatment, although the autophagy inducing signal was constantly transduced.
As the sperm became fully mature, the researchers found, the burst of cAMP was inhibited, which is probably a good thing: Sperm would quickly burn out if cAMP was constantly stimulated.
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