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The high fraction of ligand bound to plasma proteins, probably resulting from a relatively high lipophilicity (logD at pH 7.4 is 2.95 [40]), may be the reason for the slow propagation into tissue and the constantly high activity concentration in blood vessels dominating signal in healthy tissue (suggesting similarities to [11C](R -PK11195 in vivo) [41, 42].
In petunia, the AOC is constitutively present in stem tissue, and has constantly high activity [ 9].
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This is attributable in part to the large variation in relative brain size across species, and in part to the constantly high metabolic activity of the brain, regardless of the behavioral state of the animal [4].
Conclusions Increased physical activity in middle age is eventually followed by a reduction in mortality to the same level as seen among men with constantly high physical activity.
Given the increasing prevalence of obesity between 2008 and 2013 but constantly high intensity of practiced physical activities, further investigation should focus on dietary habits [ 29].
In this paper, we focused on the January 2012 cluster activity in the area with constantly high seismicity and investigated the migration and stress drops of earthquakes.
Despite the robustness of these auditory responses, they are found on top of a relatively high background activity that presumably requires a constantly high metabolic rate.
The data indicate that the cluster activity in January 2012 was unique from the viewpoint of earthquake magnitudes in that the activity included several earthquakes with magnitudes around 5. Figure 3 also shows that the hypocenters of earthquakes involved in the cluster activity were located within areas with constantly high seismicity.
The activity of rHhoB in the presence of Ca2+ was constantly high at pH values between 5.5 and 6.5 and decreased slightly at pH 6.5 8.0.
Observations of high activity at foraging stands suggested that Steatornis caripensis would forage for fruit constantly throughout the night, breaking only to return to the cave [23].
Optimal methane drainage relies on two key factors: constantly high gas flow and high methane concentration.
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