Exact(8)
Dipeptides concentration in medium (closed circle) decrease with slow and constant uptake rates (qs, Δ).
Cell assays showed a constant uptake and internalization over the whole experiment.
A two-compartment model analysis was previously developed to assess radiotracer uptake in tissues, assuming constant uptake and release rates, K (min−1) and k R (min-1), respectively (in comparison with the three-compartment model of Sokoloff et al. [13], K is (k 1 k 3) / (k 2 + k 3) and k R is (k 2 k 4) / (k 2 + k3)).
To determine the uptake ratio we chose the mediastinum as reference since we observed constant uptake for [18F]FLT and [18F]FDG in this region.
Also tumor retention could be significantly improved with almost constant uptake up to 4 h after injection.
This analysis shows that uptake was proportional to the total energy input below approximately 100 J, which then saturated at a constant uptake value at higher energy inputs.
Similar(52)
Fig. 9 Dipeptides are transported by different mechanisms into the intracellular matrix (slow-constant uptake qs1 and fast-variable uptake qs2) where they are digested and their constitutive amino acids are either used for cell metabolisms (closed circle) or expelled from the cell (open circle).
In equations (4) and (5), n u and n q are the number of consuming and releasing cells within the diffusion grid, respectively, K MM is the Michaelis-Menten constant for uptake, v m is the maximum uptake rate per cell, and ρ is the release rate per cell.
This approach should reflect the relatively constant glucose uptake capacity of the tissue rather than the instantaneous uptake rate, more or less independent of variations in blood glucose.
The pharmacokinetics over 24 h shows a relatively low but constant tumor uptake over 4 h and is still visible after 24 h (Fig. 8b) while the uptake in heart declines.
For the short-term simulation, the ratio between the actual transpiration (Ta) and potential transpiration (Tp) approached almost ∼1.0 due to the constant groundwater uptake.
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