In vitro release results showed a nearly constant release rate for up to 8 weeks.
A constant release of active gentamicin for over 28 days was found.
However, these dispersion simulations are typically modelled with constant release rates leading to steady state results.
The carrier was intramuscularly (IM) injected, where cellular activity played a role in achieving the goal of constant release.
With water-activated, pH-controlled silicone reservoir devices, both the rate of drug release and the duration of constant release were controlled.
A low molecular weight copolymer (1200 g/mol) with low polydispersity has promising properties with a constant release profile, good biocompatibility and injectability.
The release of drug from tablets coated in acetone showed a profile more close to a zero-order constant release profile.
Osmotic pressure-driven drug release from rubbery polymer matrices in a cylindrical geometry has been shown to produce a period of nearly constant release.
Significantly, The PCL-b-d,l-PLGA50 copolymer microspheres showed good release profiles with a nearly constant release during 20−110 days.
Interestingly, constant release rates can be realized for a period of two weeks at physiological conditions in vitro, with accelerated release rates within acidic environments.
However, the build-up of senescent cells during the course of one's lifetime can contribute to a number of age-related diseases (arthritis and diabetes, to name a couple), stemming from their constant release of inflammatory molecules.
