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Although correction for regression to the mean provided unbiased estimates of the treatment effect under a constant disease process model, this correction also overestimated the treatment effect when disease activity changed over time.
Such factors might be expected to give rise to a fairly constant disease incidence rate.
Complications are common but not a constant: disease progression is marked by severe colitis, strictures and perianal fistulas, typically requiring surgery [ 6, 7].
Similar lack of knowledge was found in a study from India: "Both patients and medical practitioners displayed a lack of comprehension of the need for constant disease monitoring and consistent approaches to tight glycaemic control" [ 18].
The change in A(1) was described by a constant disease progression rate (RATE) plus an additive term (A(1) × α) in which α was a parameter for the individual change in progression rate.
Following adjustment on the prognostic score as a variable, the strata factor became significant (RR = 0.657, P = 0.0002) indicating that PSP patients on the whole had a worse prognosis compared to MSA patients at constant disease severity and disease duration at entry (Supplementary Fig. 1B).
Similar(53)
ERBB2 status remains constant as disease progresses to invasive and then metastatic stages.
We used the function as proposed by Post et al.: 15 2where kestrogen is the first-order rate constant of disease progression.
PBC is a constant liver disease featured by damage of intrahepatic bile-duct and cirrhosis and the appearance of highly specific antimitochondrial antibodies and autoreactive T-cells indicated its autoimmune nature [ 71].
The relative fitness in sex 1, with respect to the ith locus, is as follows: where s i = cγ i > 0, and c is a positive constant relating disease to fitness (hence, the fitness ranking in the focal sex follows the order A n, i A n, i > A d, i A n, i > A d, i A d, i ).
Travel, transportation, trade, pollution, and ecological disruption all play a role in assuring the constant flow of disease from one part of the world to another.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com