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Mr. Criner's fellow jurors were not thrilled about his literary ambitions either, because they thought that his constant copying of exhibits into notebooks -- so that he would have them ready to draw on later -- slowed down already painful deliberations.
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The adaptive weights smoothing-based algorithm GLAD [25] for identifying regions of constant copy number was used.
For analysis of GNL differences, chromosomal segments were defined as genomic regions with a constant copy number for all samples.
In ColE1-type plasmids an efficient regulation mechanism has been evolved, that helps to maintain a constant copy number by counteracting occasional deviations from the steady state level.
Average divergences were calculated for the seven core elements with constant copy number and for the 46 core elements with CNVs.
The KDM1 genes have maintained a constant copy number of two in most animal species from the basal invertebrate sea anemone to human, except for insects and several nematodes, which contain one and three copies, respectively.
After proper normalization and transformation of the raw signal intensities obtained from such technologies, the next step is usually to perform segmentation to identify regions of constant copy number.
To analyze the chromosomal regions that differed between xenografts and patient tumors, a "GNL difference" was calculated for each chromosomal segment: a segment was defined as a region with a constant copy number for all samples.
In the AOD family, the plant group I KDM1 genes were duplicated several times before the diversification of flowering plants and further in specific lineages, whereas the animal KDM1 genes have been maintained with a constant copy number in most species.
The log2-transformed normalised data were then pre-processed to average any on-slide replicates using the 'snapCGH' package from Bioconductor and segmented into local regions of constant copy number by circular binary segmentation (Gentleman et al, 2004; Olshen et al, 2004).
Your eyes are a constant lens, copying so many things".
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