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In those patients, more intensive chemotherapy, including early HSCT can be a replaceable solution instead of routine consolidation protocol.
Fifty-four (78%) of the patients entered complete remission (CR); 27 of these then received a consolidation protocol consisting of daunorubicin, cytosine arabinoside and 6-thioguanine, followed by two courses of intravenous methotrexate 500 mg m-2 with folinic acid rescue.
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In the bacteriophage-treated mice, moderate or mild lesions of alveolitis and bronchitis were observed without necrosis or consolidation; in a blind protocol, the severity of these histological lesions was scored at 5 out of 25 (Figure 3B and M).
With the consolidation and divulging of the protocol, the number of beneficiaries might be greater.
All received a standard leukaemia-based protocol with intensive induction, consolidation and continuing chemotherapy.
Previous reports detailed relapse data after protocol-defined termination without consolidation therapy [ 19, 22, 26, 27].
Based on improvements in EFS after myeloablative consolidation, single and limited institution clinical protocols have tested varying approaches to intensifying consolidation therapy(ref. 5, 6).
Both protocols consist of an induction, consolidation, re-induction (only for HR) and maintenance phase.
Allogeneic HSCT should be performed in CR1 after consolidation according to the AML CR1 HLA id protocol.
Additionally, CT scans were performed 8 10 weeks postoperatively with the same scanning protocol as preoperatively to assess bony consolidation.
Such an anterior consolidation generates the C-profile in the BLUE-protocol.
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