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The total training sequence requires 7 days of course attendance (3-day course followed 4 months later by a 4-day consolidation course), 20 hours of internet based training [23], performance of a 300 image portfolio, and a high stakes board-type examination.
Whilst not universally successful, approaches that utilise a 2 3 week course of parenteral ceftazidime, followed by a 3-month consolidation course of oral.
A consolidation course, consisting of intermediate-dose cytarabine (A) and idarubicin (I) followed by hematopoietic stem cell transplantation (HSCT) was planned for patients in complete remission (CR).
In the AML 10 study of the EORTC and GIMEMA LCG [ 34], one of the three arms used daunorubicin as anthracycline, but the patients without a donor received an autologous stem cell transplantation after the first consolidation course which was identical to the intensive consolidation course of the AML 8B study.
The antibody was given to patients in complete response/unconfirmed complete response (CR/CRu) or partial response (PR) after chemotherapy as a short consolidation course to avoid excessive toxicity.
Büchner et al. compared after three intensive courses of remission induction and consolidation therapy the efficacy of 3-year maintenance versus only one additional intensive consolidation course containing high-dose Ara-C.
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Both arms included daunomycin in the consolidation courses [ 20].
This indicates that administration of intensive consolidation courses is more problematic in patients older than 45 years.
In this patient, ATRA was reintroduced uneventfully in the following consolidation courses consisting of idarubicin, cytarabin plus ATRA, mitoxantrone plus ATRA, and idarubicin, cytarabin plus ATRA.
Following normalisation of serum hCG levels (<5 IU l−1), treatment was continued for another 6 weeks (three consolidation courses), where after lifelong follow-up of hCG levels proceeded.
Two consolidation courses of high-dose cytarabine have since been given, with the patient remaining in CR 6 months after diagnosis.
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