If a significant amount of gum Arabic was applied as a consolidation agent, it might be possible to see a layer of it above the paint layer, however, as is shown in Fig. 6b, no coating layer is seen at a resolution of 1.2 μm.
Ongoing randomized studies may further elucidate its role as consolidation agent for aggressive lymphoma and within the framework of an ever-changing lymphoma standard of care.
The clinical evidence discussed above supports the role of Y-IT as a useful consolidation agent after induction chemotherapy for lymphoma.
Several recent clinical trials have been designed to evaluate the efficacy and feasibility of sequential treatment strategies, for example, induction with novel agents, consolidation with ASCT, and maintenance with novel agents.
Considering the result of this and earlier [ 11] analysis, single agent ch14.18 consolidation appeared to prevent late relapses.
Small patient series of consolidation therapy with single agent chimeric MAB ch14.18 [ 7, 8, 10] or murine MAB 3F8 [ 9] had shown encouraging results in high-risk neuroblastoma patients.
Other non-Europeans could also be agents of consolidation.
Some factors tend to delay this process, such as institutional inertia, poor coordination and cooperation mechanisms among sectors, levels of government and agents, the consolidation of the biomedical paradigm reinforced by lobbies and cultural patterns, and inadequate collaboration among experts, practitioners and health authorities.
The Southwest Oncology Group-Intergroup Trial S0220 was designed to incorporate an active systemic agent, docetaxel, as consolidation therapy.
The concept of consolidation, using a non-cross agent treatment started before tumor progression, also referred to as an "early second-line", has been investigated in several trials.
As response and progression-free survival rates were similar to those reported in GERCOR trials of dual chemotherapy, two-drug treatment followed by consolidation therapy with a third agent was suggested as a feasible approach.
