Gill, H. S., DeVane, C. L. & Risch, S. C. Extrapyramidal Symptoms Associated With Cyclic Antidepressant Treatment: A Review of the Literature and Consolidating Hypotheses.
While the clinical finding that female sex is a risk factor for aSAH consolidated this hypothesis, it has only been demonstrated in older cohorts (>50 years) [ 7– 9].
This experiment concurs with the observed synteny conservation and then consolidates the hypothesis that the remaining five genes (ACIAD3536 3540) may be candidates to fill the observed reaction holes.
To further consolidate this hypothesis, we performed an established test to measure depression in rodents, the tail suspension test, which determines over 6 min the time mice spend immobile.
However, a longitudinal follow-up of these participants will be required to consolidate this hypothesis, since it is possible that biases such as a survival bias might have influenced the cross sectional results noted above.
In the future it might be possible to consolidate on one hypothesis, given that more functional data about these hypothetical proteins are being gathered and higher quality sequence information becomes available for phylogenetic analysis.
Second, pooling enhances the power of statistical tests, because it reduces the number of simultaneously hypothesis tests by consolidating the redundant sibling probe sets into one probe set.
Once the fiducial landmarks are consolidated, they generate hypotheses for the positions of the remaining 15 "unstable" landmarks, which are refined then with another application of SVR.
However, it is equipped to address the issue of putative target evaluation, and ultimately, to provide a means of consolidating existing mechanistic understanding into a platform for hypothesis testing and decision support.
