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In this article, we show that the dynamical aspects of cellular functional regulation cannot be inferred from the sensitivity coefficients of PSA, neither directly nor as consolidated sensitivity metrics.
The sensitivities of x6 with respect to all model parameters are ranked in Figure 2 using consolidated sensitivity metrics, i.e. infinite norm [ 44]), FIM [ 43]), and time-integral [ 34]), and using sensitivity magnitudes at switching time (t = 7.12 time units; Figure 2(d)).
As the state and parameter values may span a large range of magnitudes, normalized sensitivity values are often used to compare among states and parameters and to generate parameter ranking, which is given by: (8) In most systems biology applications of PSA, parameter rankings are generated from the sensitivity coefficients, either directly or using some consolidated sensitivity metrics.
In many applications, PSA is used to generate parameter ranking based on the magnitude of sensitivity coefficients, either taken at a specific time or using consolidated sensitivity metrics, such as time-integral or average or norm of sensitivity coefficients [ 34, 43, 44].
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Correspondingly, the use of any time-consolidated sensitivity metrics will only worsen this problem.
Starting from the consolidated coupling between flux analysis and sensitivity analysis, a methodology based on curve matching and functional data analysis was developed, through which the importance of a species in the target accuracy is assessed via a proper metric.
People with this type of insomnia, who likely have more sensitive circadian rhythms and a greater sensitivity to light, may be better suited to biphasic rather than consolidated sleep. .
This chapter explains consolidation in clays, focusing on normally consolidated and over consolidated clays.
The rankings of the important parameters that control caspase-3 according to the PSA are shown in Figure 6, using consolidated metrics: infinite norm [ 44]), FIM [ 43]), and time integral [ 34]), and using the sensitivity magnitudes at switching time) (see Additional file 1: Supplementary Figure S3 for detailed sensitivity rankings).
However, more consolidated weighting systems to enable comparison of different passive strategies should be incorporated in green building rating tools based on further sensitivity and parametric studies.
His social position was consolidated.
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