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The identification of bona fide miRNA molecules usually requires a complicated pipeline consisting of a computational search, the detection of the molecules among reads of small RNA sequencing surveys and, finally, the functional identification of the miRNA-target interactions.
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The largest test problem performed with this code consists of a computational mesh of 4096 × 64 × 64 (16 million) cells, a total of 256 million particles, and corresponds to a plasma volume of 50 μ m × 20 μ m × 20 μ m (approximately 150 λ×60λλ× 60λ, where λ is the laser's vacuum wavelength).
The program consists of a computational core that is accessed and controlled through a GUI (Figure 1), both written in Matlab.
The core of PINA consists of a computational pre-analysis of the molecular interaction network aiming at identifying clusters of densely interconnected nodes, which are likely to represent sets of functionally related proteins.
Each of these modules consists of a computational core as a shared library of C++ code and a set of Python modules built on top of the exported API.
To determine the biological relevance of the differential DNA methylation in pancreatic islets, we followed a two-winged strategy consisting of a combined computational and literature approach on one hand, and on the other hand in-vitro experiments to uncover the functions of genes that were previously unknown in the context of pancreatic islets and/or β-cells.
The use of the notation is evaluated by a detailed example of an integrated tangible agent consisting of sensors, a computational part, and actuators.
This is done by constructing a computational domain consisting of a central thin plate and two wedges.
Generally speaking, artificial neural network (ANN) can be described as a computational system consisting of a set of highly interconnected processing elements, called artificial neurons, which process information as a response to external stimuli.
9 In order to assist in the interpretation of these clinical results, we devised a computational model consisting of a finite element electric field model of the DBS electrode, coupled to populations of multicompartment cable models of myelinated axons.
The individual-based model used in simulating the data in this study is a computational epidemiology model consisting of a disease model and a dynamical network with detailed representation of synthetic populations [ 9- 11].
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