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This can be explained by intra- and inter-tumor heterogeneity, a technical inability to consistently verify the presence of the biomarker in patient's material, and the lack of specificity for a particular disease.
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If the company's data is consistently verified by my anecdotal experience then I'll be back for more.
Subsequent studies have consistently verified the importance of one of the genes disrupted by this translocation (DISC1).
Our study produced three main novel findings which were consistently verified by different statistical approaches.
Clinical studies have also consistently verified the estrogenic effects of tamoxifen on the vaginal epithelium [ 42- 47].
The homozygotes could be readily identified by root growth and root hair phenotypes and were consistently verified by spot-checking with PCR).
All measurement properties were consistently verified across the two studies, supporting the validity of the HIT-6 among chronic migraine patients.
However, the beneficial effect of PRP on cartilage regeneration in rabbits could not be consistently verified in larger animal models, including sheep and goats.
The collected data, SAE forms and CRFs were not consistently verified in comparison with the source data in the patient files, but the forms were systematically screened for plausibility and completeness.
This leads to the hypothesis, clearly and consistently verified in this study, that sample preparation procedures based on a protein extraction step (such as FASP and ISD) may imply a depletion of high-MW proteins compared to methods founded on a whole tissue trypsinization.
The FGFR2 and TOX3 SNPs have consistently been verified in published reports (Huijts et al, 2007; Gorodnova et al, 2010; Hemminki et al, 2010; Turnbull et al, 2010), whereas replication of the other low-penetrant SNPs has been less constant.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com