Among the few repair genes consistently regulated with age, the down-regulated genes (CEP164 and TP53) are also related to the cell cycle.
There was a remarkable variation in gene expression over time and of the 16 K reporters interrogated, only those for mt2 were consistently regulated in one direction (up-regulated) throughout the experiment.
Other genes which were significantly and consistently regulated were FAS and EL (both up-regulated when VO replaced FO in the diet), while GST, HOX and AGPAT only showed significant regulation in Fat fish.
Interestingly, we only detected an overlap of regulated genes in light, with most of the consistently regulated genes being upregulated.
There are two clusters that are enriched in immune response functions, and each is consistently regulated in mouse and macaque, but they show differential regulation in the Calu-3 cells.
Filtering out the head injury papers from Lukasiuk et al's study leaves only four consistently regulated genes, three of which are included in our list of regulated genes (Gadd45a, Ctsd, Ctss, Zfp36).
"It's important to know that coal ash ponds and landfills are currently less consistently regulated than landfills accepting household trash," Galland explains.
Its price points were consistently regulated by the government, which meant that the company could pursue technological advances without being hidebound to knowing--out of the gate--how the results would be implemented and monetized.
