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With this double filter, we guaranteed that the survived enriched categories are the ones consistently enriched in the GEP studies on prognosis of CRC.
This way, we overcame the lack of reproducibility observed in both the genes reported in individual GEP studies and the overrepresented categories reported by enrichment analysis tools, and could identify consistently enriched categories.
It is impossible for me to itemize the myriad of ways that my life is consistently enriched by my husband.
The "endomembrane system" cellular compartment category was consistently enriched in genes with significantly altered expression.
Among the four patients the genes selected from the integrative genomics approach were consistently enriched for H3K27me3.
Interestingly, the proportion of CD44+/CD24− cells was not consistently enriched by the spheroid culture method (Table 1).
To avoid false positives, we applied two stringent selection thresholds before we considered a category as consistently enriched.
Although the pattern varied between cell and even between individual processes, calpain-2 was consistently enriched in the incipient sprouts and populated the vast majority of neurite tips.
We selected only those categories which were reported to be overrepresented by several tools and in at least two of the three gene lists as consistently enriched categories.
From them, only the categories common in at least two of the three gene lists were considered to be consistently enriched.
In fact ABCA1 was consistently enriched at the edges of the phagocytic cup, whereas MEGF10 was dynamically recruited at its rim.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com