Consistently, animals deficient in IL-12 are also unable to control Mtb infection and die of the progressive disease [10, 11].
Consistently, cells deficient in both RHOBTB3 and LIMD1 have higher levels of HIFα than cells lacking either protein alone.
Consistently, mutants deficient in PEP4 (Δ pep4) exhibit reduced protein degradation and enhanced loss of viability under conditions of nutritional stress.
Consistently, leptin-deficient (ob/ ob) mice and leptin-receptor deficient (db/ db) mice are not only obese, but also exhibit important hormonal imbalances, infertility, abnormalities in thermoregulation, and evidence of immune and haematopoietic defects [ 1- 4].
Consistently, podocalyxin-deficient mice fail to form foot processes and slit diaphragms and die within 24 h after birth with anuric renal failure [39].
Consistently, NPGPx-deficient mice exhibited markedly increased fat mass and adipocyte hypertrophy.
Consistently, AEBP1-deficient mice exhibit increased PTEN levels and suppressed Akt activation.
Consistently, NPGPx-deficient mice exhibited markedly increased fat mass and adipocyte hypertrophy, while treatment with NAC ablated these phenotypes.
Consistently, BRCA2-deficient cells fail to show RAD51 nuclear foci formation in response to DNA damage (152).
Consistently, leptin-deficient mice are not only obese, but display major hormonal disturbances, including hypercorticosteronemia, diabetes, and infertility.
