Within both subject groups (with the exception of C5a in the patients' group), carriers of the CFH risk haplotype showed consistently higher complement activation parameters than those carrying the protective haplotypes.
Multiple sclerosis plaques were consistently positive for complement proteins (C3, factor B, C1q), activation products (C3b, iC3b, C4d, terminal complement complex) and regulators (factor H, C1-inhibitor, clusterin), suggesting continuing local complement synthesis, activation and regulation despite the absence of other evidence of ongoing inflammation.
These lists were consistently populated by complement-related genes and many of the signature genes enriched in the uninjured epicardium (11 downregulated genes were among those 26 signature genes with a fold difference above 25, while the other 12 were among the remaining 171 signature genes with a lower fold induction).
Consistently neither mutant could complement the Δ espG mutant by inhibiting the recycling of the TfR (Fig. 5E).
Overall, the most robust main effect was that of sex chromosome complement, which consistently caused lower gene expression in XY- compared to XX mice.
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Furthermore, in addition to albumin, several apolipoproteins and complement components have consistently been found in association with serum granulations.
The levels of proteins that participate in leukocyte extravasation and complement pathways were consistently increased in the normal, aged RPE/choroid.
The most over-represented GO process, complement activation, scored consistently high in all data sets examined with nine out of thirty five genes activated (p-value 2.5e-8).
The T12/T0 ratio for other proteins known to be associated with the acute-phase response, such as ceruloplasmin and complement proteins, was consistently lower in the R group compared with the NR group, suggesting that with successful therapy there was a greater reduction in the absolute levels compared with baseline.
