This result is consistent with the trafficking defects seen by proximity labeling with Sec23 or Sec13 (Fig. 5), and further demonstrates that defects in assembly or trafficking of the complex produce a global reduction of the ERGIC.
Importantly, these increases are not accompanied by changes in total AMPAR levels, consistent with the trafficking of AMPARs from internal synaptosomal compartments into synaptic sites.
Importantly, we observe an increase in the levels of GluR1 and GluR2 AMPAR subunits in the postsynaptic density (PSD) fraction, without changes in total AMPAR levels, consistent with the trafficking of AMPARs from internal synaptosomal compartments into synaptic sites.
All 3 lines localise in basal puncta, consistent with the trafficking of iron-loaded ferritin through the Golgi (Missirlis et al., 2007).
We will see in the following subsections how differences across countries may impact the conditions for invasion, and will quantitatively assess within this framework the role of travel reductions consistent with the traffic drop observed in the traffic to/from Mexico.
Such characteristic is consistent with the traffic hours when people go to work in the morning and come home from work in the afternoon.
In addition, although aircraft related noise has a different profile from that of traffic related noise, our findings are consistent with the traffic noise-cardiovascular disease health literature.
We found an increase in unprocessed procollagen, consistent with a trafficking defect (Fig. 3S).
In CTB positive motor neurons with a normal Golgi apparatus, a proportion of CTB codistributed with GM130, consistent with retrograde trafficking of CTB to the Golgi apparatus.
Similarly, mutant Myo7a, Ush1c and Cdh23 mice form fewer mechanoreceptor lateral links (Lefèvre et al., 2008), consistent with decreased trafficking of these components.
