This is also consistent with the changing epidemiology of type 2 diabetes, the incidence of which is rising [ 24], with patients diagnosed at a younger age and living longer due to improved cardiovascular outcomes.
This move is entirely consistent with the changing landscape for drug companies and its prospective effect on promotional spending and tactics.
According to Le Boterf as reported in Brahimi [ 12] "the concept of competency has to be consistent with the changing contexts and situations in the workplace".
3. Updating and where necessary amending the national strategies is important for ensuring that the policies and programmes for sustainable food security at national and household level remain consistent with the changing socio-economic and food security situation in each member country.
In addition, the study results provide evidence for the dominance of CTX-M-15-producing isolates in Saudi Arabia [ 9, 10, 12, 13, 17] and that the predominance of ST131 is likely responsible for the clonal expansion of ESBL-EC in Saudi Arabia, conclusions that are consistent with the changing epidemiology of ESBL-EC worldwide.
In addition, study results supported the evidence that the rising prevalence of CTX-M-15-producing E. coli not only in the community but also in the healthcare settings, and the predominance of ST131 responsible for clonal expansion of ESBL-producing E. coli in Korea, which are consistent with the changing epidemiology of ESBL-producing E. coli worldwide.
Consistent with this observation, changing the steric bulk on the amine of L13 gives a range of ee values for 4 (see L20), whereas changing the steric environment of the phosphine does not significantly perturb the selectivity (see L19).
Consistent with this hypothesis, changing the VSD-pore interactions directly via a single point mutation also prevented the intermediate-open state and modified the properties of the activated-open state.
