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Nevertheless, our SMBG results are consistent with the trials showing a statistically and clinically significant effect of SMBG.
The most common adverse event in the varenicline group was nausea, which is consistent with the trials of varenicline for smoking cessation.
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Data from a human buccal cell line TR146 were consistent with the trial results.
This is consistent with the trial population as a whole, suggesting the sample is representative of the wider trial, although participants in the present study tended to be older.
The data from the electronic container group appeared to show a small initial increase in adherence that reduced gradually over time, which could be interpreted as being consistent with the trial results.
Such an approach would be consistent with the Trial for Activity in Adolescent Girls (TAAG) in which a project champion was used to maintain interest in a school-based physical activity intervention once the content sessions were removed [ 29].
Moreover, the lack of VOR-decrease learning in response to optogenetic climbing fiber stimulation was consistent with the trial-by-trial analysis, which found no evidence for a contribution of the natural, visually-elicited error signals in the climbing fibers to the induction of VOR-decrease learning.
Consistent with the trial protocol, the following English measures were completed at randomisation (followed by other trial measures): (a) BDI-II [ 5] (b) Researcher-rated Montgomery-Asberg Depression Rating Scale [ 13] (c) SF-12 v2 [ 11] (d) EQ-5D [ 9] For the validation study, participants were also invited to complete the Welsh BDI-II.
The base case model timeframe will be 20 weeks consistent with the trial follow-up and all costs and outcomes will be extrapolated for at least 10 years, with an annual discount rate of 5% applied to both costs and outcomes, to estimate future expected costs and benefits.
The findings in our patient population suggest that the efficacy of COX-2 inhibitors could be quite limited in ER-positive breast cancer, consistent with the trial results by Dirix et al. [ 12] and Falandry et al [ 18], suggesting that the benefit of these inhibitors as a therapeutic could be strongest in the ER-negative or HER2-positive disease.
The model is consistent with the experimental trials and showed that cracking originated from thermal stresses developed in the titanium epoxy aluminum system due to the PVD process.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com