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The series of 172 upregulated genes was enriched for GO terms consistent with the tip cell phenotype in vivo, such as angiogenesis, regulation of cell migration and blood vessel morphogenesis (Fig. 7b).
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We first derive two important formulas and then find that these path-independent integrals are in fact identical to each other and consistent with the crack tip energy flux.
The intracellular positioning of the polarity complexes, while retaining their longitudinal positions relative to each other, was asymmetrically skewed towards the barrier, consistent with the overall tip morphology (Fig. 1A).
This result is consistent with the root tip expression patterns of WOX5 and PLETHORA transcription factors, which are believed to be regulated downstream of auxin signaling to control stem cell activity [ 42].
This is consistent with the hypothesis that tip growing cells suffer anoxia, an hypothesis long set forth for pollen tubes [ 72], and known to have specific adaptions in root hairs [ 73].
The extent of unfolding of holo-Mb obtained in the rapid mixing experiments in this study is less than that reported earlier, a result that is consistent with the much smaller tips used in the current experiments.
The chemical shifts of the resonances, and the magnitudes of the silicon phosphorus coupling constants, indicate that the resonance at −1.8 ppm corresponds to a saturated Si(Tip 2 moiety at two bonds from the phosphorus atom; the more upfield resonances are consistent with Si(Tip) groups with single bond coupling to a phosphorus nucleus.
The location of filament plus ends at the tip is consistent with the restriction of the WAVE nucleation complex to the actin-membrane interface [21]; Supplemental figure S1 and Supplemental text S1).
Most of the GRASP fluorescence was at proximal and medial regions of the ASP, and little was near the distal tip, consistent with the observed distribution of myoblasts.
Microarray analysis of the CD34+ and CD34− HUVECs further demonstrated that CD34+ cells display a gene expression profile that is consistent with a tip cell phenotype.
Again, this is consistent with tendril tip cells migrating over an uncolonized area where iron resources have not been yet depleted.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com