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The anhydride peaks indicate that the anhydride remained intact in the copolymer, and the shift to higher frequency (higher energy) of the ester and amide carbonyl stretch is consistent with the elimination of the conjugation of the vinyl and carbonyl double bonds.
Such patterns are consistent with the elimination of cell cycle checkpoints and suggest that an event subsequent to division was responsible for the definitive failure of atm to recover from the IR in primary and secondary roots.
This conservation could be consistent with the elimination of most divergent structural variants by selection, indicating that observed structural variation is below a selection threshold.
As expected, polymorphisms are rare in sequences important for pre-mRNA splicing in S. cerevisiae, consistent with the elimination of deleterious mutations by purifying selection.
As would be expected, UGE returned toward the baseline value in each group within 1 3 days after treatment discontinuation, consistent with the elimination of the last dose of luseogliflozin.
DNase treatment caused a delay in the Xist signals arising from female embryos (green lines), consistent with the elimination of all 42 copies of genomic Xist DNA in each embryo plus some decrease in the number of Xist transcripts.
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The assumption that the complex elimination rate was much faster than the dissociation rate was consistent with the rapid elimination of SAP, indicating rapid association rate, KON, and KINT relative to KOFF.
Trough concentrations, obtained from blood samples collected 7 days post dose on Weeks 2, 3 and 4 suggested that steady-state levels had not yet been reached by Week 4 (concentration: 464 µg/mL), and were consistent with the slow elimination of this compound.
Consistent with the long elimination half-life, some accumulation in the deep distribution compartment appeared to occur after the fourth administration (within cycle 1) of cabazitaxel, with a significant increase in exposure (AUC0-t).
By 120 min following injection, absorption by each organ had markedly reduced, indicating that the target product was consistent with the fast elimination characteristic of polypeptides in the organism.
The in vivo forskolin and 1,9-dideoxy forskolin antileukaemic activity and the low toxicity are consistent with the long elimination half-life assessed in healthy individuals and with the absence of toxicity in mice treated with these compounds (Kikura et al, 2004; Neviani et al, 2005).
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