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Consistent with PROactive, a meta-analysis of all pioglitazone studies published (excluding PROactive) and reported to the FDA demonstrated a 25% decrease in cardiovascular events (145) (Fig. 6 B ), and a recent review recommended that pioglitazone should be considered in diabetic patients with cardiovascular disease (146).
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In the current study, several anatomical regions showed effects consistent with both proactive control during the HE condition and reactive control during the LE condition.
This pattern is consistent with impoverished proactive control of attention resulting in RT slowing on Go trials being required to maintain No Go accuracy levels.
In the trial-based emotion contrast (Pos Neut vs. Pos Pos), RTs showed a pattern consistent with increased proactive control (slowing in AY but speeding in all other trial types, although the overall effect was very small, <10 ms).
Incentive effects occurred in both block- and trial-based contrasts, enhancing performance in all trial types except AY, which was characterized by sharp increases in errors with both block and trial manipulations; this pattern is consistent with increased proactive utilization of contextual cue information.
Firstly, gender was consistently associated with proactive aggression.
This is a reality that Sloan will have to be aware of and ready to successfully overcome with proactive, consistent and transparent communications.
This temporal distinction is consistent with the differentiation between proactive and reactive control mechanisms in the DMC model.
This cross-over dynamic is consistent with a shift to proactive control (engaged during encoding and WM maintenance periods) from reactive control (engaged primarily during response periods) that we have observed in prior work.
This enabled us to investigate whether the patterns of DLPFC functional connectivity observed were consistent with differential engagement in proactive control of sustained attention versus off-task thought.
These data are consistent with results from the PROactive Study 1 and a report suggesting that rosiglitazone use was associated with a 5%, non-significant, reduction in mortality 16.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com