These phenotypes are consistent with our proposed role for nutrient depletion-induced replication stress in chronological aging.
The distribution of sufD in aerobic microorganisms encoding suf is consistent with our hypothesized role for SufD in iron trafficking during Fe S cluster biogenesis.
Taken together, these results provide a link between the dysfunction of the endosomal sorting machinery and neurodegeneration and are consistent with our proposed role of SigR1 as a regulator of endosomal sorting, MVB formation and endosome-to-lysosome trafficking of membrane cargo.
We analyzed the distribution of Yme2-GFP foci in Δgem1 cells and we have added representative images to Figure 4. We observed that like ERMES, Yme2-GFP is predominantly localized to mitochondrial constrictions, consistent with our proposed role of ERMD in nucleoid distribution.
RNAi of only FLN1 in tobacco resulted in chlorosis, consistent with our proposed greater role for FLN1.
The recent finding that salinomycin, an inhibitor of K+ transport, is a selective inhibitor of cancer stem cell proliferation is consistent with our findings on the role of KCNMA1 in melanoma cells [63].
Analyses of US Civil War veterans suggest that recent declines in disability rates were a continuation of declines in both chronic disease and disability occurring over the past century due to improved nutrition, sanitation, and education [79] which is consistent with our finding of a role for SEP in explaining variation in physical capability levels.
Consistent with our studies indicating a role of the A1AR in mediating acute responses to adenosine bolus injections, other studies from Bertil Fredholm's group indicated that the A1AR is involved in the regulation of heart rate, body temperature and locomotor activity, but the magnitude of the involvement is different in males and females [31].
It is interesting that ROCK inhibitors that inhibit Rho-mediated cytoskeletal tension can promote self-renewal and pluripotency and reduce apoptosis of hESCs [49], consistent with our ideas on the role of low tractions on self-renewal and pluripotency of mESCs.
These findings are consistent with our data demonstrating a role for NTE catalytic activity in vertebrate development and motor neuron maintenance.
A large number of zinc cluster transcription factors regulate drug resistance, consistent with our observations on the role of CZT-1.
