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That seems consistent with demonstrations that HPA activation and glucocorticoid hormones may contribute to binge eating, drug addiction, and other excessive reward pursuits [ 22, 55].
The hypothesis is also consistent with demonstrations in two-headed molecules that catalytic turnover of the two heads is not independent, at least under some conditions (9− 11).
Evaluation of ΔQTcP across all time points during placebo infusion demonstrated a large fluctuation between early time points in the ECG assessment window, likely reflecting instability of variables such as insulin and glucose concentrations post-prandially and consistent with demonstrations of an effect of food consumption on QTc [ 29] (data on file, Amylin Pharmaceuticals , Inc.
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These results are consistent with demonstration of expression of TG1, TG2, TG3, and TG5 in the brain (Kim et al. 1999; Bailey and Johnson 2004; Bailey et al. 2004) and together with cell biological studies points to a highly complex regulation of TG genes in the CNS.
More interestingly, the optimal control solution and proposed implementation strategy are consistent with empirical demonstrations but provide mathematical evidence that the flux may be increased dramatically by precise timing of the forward and backwashing cycles.
This notion is consistent with numerous demonstrations that lipid rafts contain a number of putative zona pellucida receptors, undergo a marked capacitation-associated lateral migration to the apical region of the sperm head, and possess the ability to selectively bind to the zona pellucida of unfertilized, but not fertilized oocytes.
This result is consistent with earlier demonstrations of Pho4 and TBP interaction in vitro [45].
This is consistent with prior demonstrations that a length release of activated fibers results in a substantially complete crossbridge detachment and increases myoplasmic Ca2+ [41], reflective of Ca2+ release from activated, Ca2+-bound thin filaments.
The latter is consistent with previous demonstrations that AP-1 augments the NF-κB regulatory program [ 35].
In contrast, consistent with previous demonstrations, vascular cell-specific deletion of AR did not reduce circulating testosterone levels and, therefore, no exogenous androgen administration was required.
This result is consistent with previous demonstrations that endogenous TPIs decrease the performance of M. sexta [ 33] and with the central prediction of the Optimal Defense theory, namely that defense is costly [ 23, 35, 37].
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