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The concept of cognitive reserve originated in the late 1980s, when researchers described individuals with no apparent symptoms of dementia who were nonetheless found at autopsy to have brain changes consistent with advanced Alzheimer's disease.
Fig. 3 X-ray of the knee: Narrowing of the joint space and degenerative changes consistent with advanced osteoarthritis.
This points to an increasingly assimilatory use of composite units, consistent with advanced use of a TNS. Figure 8d shows the solution of a probable aTNS student who uses a much less literal representation of the situation, with tally marks representing a counted cupcake and circles representing a completed box.
R6/2 mice had open-field deficits (Figure 4A) and a 12% reduction in brain weight (Figure 4B) consistent with advanced HD.
Lesions of IL-13−/ IL-13−/arrow chimeras displayed increased necrotic core formation, consistent with advanced plaque progression (Fig 6B).
We considered men presenting with symptoms consistent with advanced prostate cancer, including bone pain, weight loss or hematuria, to be "clinically diagnosed".
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The homogeneous evolution of the microstructure during annealing, coupled with no appreciable change in texture, is consistent with the advanced stages of continuous recrystallization, and also structurally and kinetically similar to conventional subgrain growth/grain growth in high-stacking fault energy, low-solute alloys.
Consistent with her advanced age is evidence of arthritis in the vertebrae at the base of her spine.
39 The safety profile was consistent with an advanced breast cancer population receiving systemic therapy.
Denosumab suppressed bone turnover and seemed to reduce SRE risk similarly to IV BPs, with a safety profile consistent with an advanced cancer population receiving systemic therapy.
The latter can also derive from the Maillard reaction [ 34]; consistent with the advanced ripening stage in dates (refer to background).
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