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The apparent correlation of expansion frequency with distance from Scandinavia is consistent with a suggested common founder rather than repeated de novo occurrence.
This is speculative but plausible, and consistent with a suggested mechanism of post-treatment facility contamination via an aging distribution infrastructure.
This is consistent with a suggested role of H3K4 methylation in transcriptional memory (Muramoto et al, 2010), which in the case of H3K4me2 may in part depend on the direct binding of factors positively mediating transcription elongation (Sims et al, 2005; Kim and Buratowski, 2009).
These results are comparable to a previous estimated date of 10 ky [1], but are not consistent with a suggested date of 60 100 ky [15], which was based solely on the apparent global distribution of selection at this locus.
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Finally, we explore sleep as a behavioral readout of TDP-43 expression and find evidence of sleep fragmentation consistent with hyperexcitability, a suggested mechanism in ALS.
This is consistent with a scenario suggested by Lin et al. [31] that incorporates the following observations: MDM2, a negative regulator of p53, is normally activated and stabilized by AKT-mediated phosphorylation [74].
Rather, our observations are consistent with a previously suggested mechanism of inducing multiple body weight set points generated by acquired leptin resistance during the high energy diets [22], [23].
This finding is consistent with a previously suggested scenario in which postprandial hyperglycaemia ('glucotoxicity') plays an essential role in the pathogenesis of islet cell failure [ 20, 21].
Our skeletal analysis revealed a decrease in cranial size in both male and female adults on the northern Channel Islands across a time period of roughly 7,500 years, consistent with a previously suggested decrease in population stature.
Our results are consistent with a previously suggested protective effect for metformin (18), more neutral effect for pioglitazone (16, 17), and potential relative adverse cardiovascular safety profile for rosiglitazone (19, 3, 4, 20).
Variation in the strength of the effect between experiments is consistent with a literature suggesting small but reliable benefits of acute exercise on cognitive performance.
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