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With MRP-positive, MDR-negative lines, only VX-710 caused consistent sensitization.
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Consistent with sensitization, the repeated application of IBA (30 sec ISI) evoked a tingling sensation that grew significantly (F4,96 = 26.7; p<0.001) in intensity (figure 2a).
A decrease in insulin levels by a combination of rapamycin and resveratrol did not lead to increased glucose levels, consistent with sensitization to insulin by this drug combination.
The magnitude of mood change in patients receiving prednisone is reportedly associated with previous lifetime corticosteroid exposure, consistent with a sensitization or kindling process whereby greater effects are observed with repeated exposure.
This observation is consistent with peripheral sensitization, leading to hyperalgesia at inflamed joints.
These hypothesized cellular mechanisms are consistent with primary sensitization (as defined in Sect. 2.2.2).
In this study, CRP was inversely associated with pain threshold at the wrists, consistent with peripheral sensitization.
This is consistent with PTP sensitization and inhibition of respiration in the course of idebenol oxidation, which we explain with generation of idebenone (Figs. 5 and 6).
The pattern of treatment failure developing abruptly in a subset of patients suggests a threshold phenomenon, and is consistent with a sensitization, or "kindling" model.
In a recent study of 59 female RA patients, we showed that C-reactive protein levels were inversely associated with pain thresholds at joint sites but not nonjoint sites, consistent with peripheral sensitization [ 65].
The lack of a consistent taxonomy for sensitization has made it difficult to decipher and relate the vast amounts of pertinent (and oft-conflicting) data from diverse animal models, sparking considerable confusion and controversy in the literature.
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