In summary, we have shown that polymorphism of the P2X7 receptor between NZW and NZB strains is associated with marked differences in P2X7-stimulated proinflammatory responses, consistent with high responsiveness and low responsiveness previously reported for the two alleles.
All this taken together shows that the consistent sexual responsiveness of individual females between experiments 1 and 3 (Fig. 1a) was not a consequence of the same individual males being used in both tests, since individual males were not reacted to in a consistent way.
This is distinct from our study of mixed PBMCs assayed by FACS in suspension (van Duin et al., 2007b), in which cells from older donors showed lower responses to all TLR ligands tested, and is consistent with enhanced responsiveness noted with progressive differentiation (Mizel & Bates, 2010).
In addition, it is known that the muscles of Thoroughbred horses have a high proportion of type IIa fibres, which is consistent with the responsiveness to daily training46.
Our studies are the first to describe the consistent and differential responsiveness of CD4+ and CD8+ T maturation subsets after stimulation with a broad panel of TLR ligands.
Consistent with its responsiveness to mechanical function, O2− production and p47phox expression, physiological levels of leptin effectively restored leptin deficiency-induced changes in the phosphorylation of Akt, eNOS, JNK, IκB and p38 in young but not aging ob/ob mice.
Consistent with AGR2 responsiveness to E2, E2 treatment in ZR-75-1 cells further induced AGR2 at the protein level.
Although results were consistent, with higher responsiveness obtained for increasing severity in vertebral fractures, the ES were rather low, except for painful vertebral fractures.
This also influenced the adherence to the exercise regimen, which has been shown to be a consistent predictor of responsiveness to behavioral therapy [ 12].
