In contrast, and consistent with promoter clusters' having active and local roles in transcription regulation, promoter clusters changed in composition between transcribed and silent genes (r 0.70/0.37, respectively).
This is consistent with promoter analysis that demonstrates the majority of tmRNA is transcribed from its own promoter (Yang and Glover, manuscript in preparation).
Contained within this cluster were microarray tiles for promoters and adjacent sequences for SCL, KCY and SIL, the +3 region, whose proposed function is consistent with promoter activity [52], and the +53 region located in the vicinity of novel transcripts.
The negative correlation is consistent with promoter methylation mediated down-regulation of MGMT expression.
In conclusion, results from chromatin IP experiments are consistent with promoter analyses through transient transfections of reporter constructs throughout.
We also list numerous hypomethylated CGIs in intergenic regions, which often harbor chromatin marks that are consistent with promoter and enhancer features.
However, in higher eukaryotes RNAP II binding is concentrated near the transcription start site of many genes consistent with promoter proximal pausing.
Therefore, for a transgene to be qualified as a potential escapee, we required consistent low promoter DNA methylation in multiple heterozygous female mice.
The corresponding human sequences displayed chromatin marks consistent with promoter and frequently enhancer activity in at least one of the cell lines tested (supplementary table S5, Supplementary Material online).
Defective expression of HOPX which is consistent with promoter DNA hypermethylation may explain aggressive phenotype of pancreatic cancer, and intense expression of HOPX in the Langerhans cells may in turn uniquely contribute to pancreatic carcinogenesis.
