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Coloured, annotated contours represent the onset times, and the contours of each panel are separated by 32 s to show consistent onset contours across wave bands.
Some locations showed a more consistent onset bias than others.
Furthermore, given the stereotyped LFP responses and the consistent onset of single-unit activations, we observed a strong phase locking in the theta band at the response time.
Although we were able to conduct detailed titrations of reduced RfBP using BA-1, BA-2, and TA-1, comparable experiments with rRNase proved to be unworkable because of the consistent onset of light scattering as the titration progressed.
However the small number of acquisitions used for the conditional Vgat experiments were not conducive to detecting and quantifying indirect IPSCs, which are more unreliable and have less consistent onset times.
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Although RTT is almost exclusively studied using the male Mecp2 Null/Y mouse model, owing to the consistent early onset of the phenotypes when compared to the more heterogeneous onset of the phenotypes in the female Mecp2 Null/+ mouse model, our study suggests that both models should be investigated when designing pre-clinical experiments.
Figure 3 shows examples of events that are consistent with onset triggering by tilted streamers that are not as ideal as the event in Fig. 1.
Fig. 3 Examples of events on 10 November 2006 and 13 October 2012 in the same format as Fig. 1 that are consistent with onset triggering by tilted streamers that are not as ideal as the event in Fig. 1.
MODY2, for example, exhibited relatively uniform dynamics for all simulations, with consistent early onset but mild hypoglycemia (indicated by moderately low insulin level).
It is possible that the increased IL-6 response seen in our study is consistent with onset of a viral upper respiratory tract infection (URTI).
In an analysis of the spread of influenza in the US over 30 years, Viboud et al. observed a consistent early onset of the epidemic in California, which is the most populous state in the U.S. [ 17].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com