Mice treated with unmodified LM showed marked reduction in metastases when killed at day 18 after initial tumour implantation, consistent with previous studies showing that this treatment induces a variety of tumoricidal mechanisms (Kim et al, 2009).
Our findings reveal that there are core transcriptional differences between the sexes that are consistent throughout pre-implantation development.
In contrast, 80% of the implanted senescent cell population is cleared from the limb tissues within 2 weeks post-implantation, consistent with a half-life of 9 days (calculated from the exponential equation corresponding to the senescent dataset, after subtraction of the initial loss observed in normal cells), comparable to the rate of clearance of senescent cells during regeneration.
The timeline of implantation was consistent with the appearance of the adverse effect.
All IVF centres experienced consistent rates of ongoing implantation, biochemical pregnancy loss and miscarriage during the study period (Table I).
For example, evidence of negative associations between TTP and serum concentrations of HCB and PCB 118 in women is consistent with findings for implantation failures associated with these exposures among women undergoing assisted reproductive technologies (Mahalingaiah et al. 2012; Meeker et al. 2011).
We never obtained homozygous transgenics from various hemizygous 5kL-1 parents (100 offspring genotyped for homozygosity), consistent with the pre-implantation lethality of homozygous ACF−/− embryos [68].
However, evaluation of nude mouse tumours formed by Caki-2 cells in orthotopic and s.c. implantations were consistent with cystic papillary RCC (Kovacs et al, 1997; Karam et al, 2011).
The SGC count results are consistent with the hypothesis that implantation results in a propensity across the whole cochlea for SGCs to degenerate and with chronic bipolar stimulation ameliorating this propensity in those cochlear segments with electrodes present.
The results here are consistent with the observation that implantation of autologous bone marrow stromal cells produced improvement in neurological defects in HD mice, experiments in which the fate of the cells was not investigated [33].
