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There is presently no disease-modifying osteoarthritis drug (DMOAD) with a consistent, documented effect despite several clinical attempts in late-stage phases.
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Although no large-scale clinical trials have been reported, ∼500 subjects have been involved to date in three randomized, controlled, and relatively well-designed studies (all funded by the National Institutes of Health) and the data have been remarkably consistent, documenting a large treatment effect (62 90% relative risk reduction).
The comptroller, Howard S. Weitzman, said he found that the company had "relied on individual appraisers' undocumented professional judgment, rather than consistent and documented measures of valuation".
The results are consistent with documented trends of thermal properties variations.
The model outputs are consistent with documented historic tephra clean-up operations.
The relative frequency of fresh versus weathered bones for individual species is also consistent with documented trends in living population sizes.
Positive findings relating to residents' competence and confidence are consistent with documented psychological benefits of physical activity on health [ 5, 30] and quality of life [ 31- 33].
The model was parameterised based on a mean incubation period of 28 days, with a range from 15 to 50 days, consistent with documented parameters [ 15].
This is consistent with documented associations between GST-L1 seropositivity and ever/never sexual activity, age at sexual debut, and lifetime number of sexual partners [ 22, 31, 40].
However, the number of women hospitalized because of AUD increased during the study in all three countries (Table 1), consistent with documented increase in alcohol consumption in women (13).
Nevertheless, the insulin glargine doses in this study are valid as they were consistent with documented real-life scenarios and so the data shown actually represent the most likely clinical expectations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com