Consistent with previous reports including aggressive disease cases, in our early-stage CLL cohort, SF3B1 and NOTCH1 were mutually exclusive and a correlation between NOTCH1 and trisomy 12 was found.
Results from the present study are consistent with those reported in a previous paper from our group [ 47], in which we demonstrated a significantly higher distribution of CD4+ T cells in patients without disease recurrence, compared to relapsing disease cases.
In addition, SNP rs1793004 in the gene encoding nel-like 1 precursor (NELL1, chromosome 11p15.1) showed a consistent disease-association in independent German population- and family-based samples (942 cases, 1082 controls, 375 trios).
Finally, in order to verify that our results are consistent with real cases of novel disease gene discovery, we use our model to prioritize 20 recently published novel disease gene mutations (Dataset 4).
Specific studies will be necessary to address this issue, but undoubtedly this type of exercise will need to be preceded by the development of a consistent case definition of 'early disease'.
Nonetheless, he added, "The outcome is consistent with other cases".
The triad of a clinical outcome consistent with disease modification, support from a surrogate marker incorporated into the clinical trial, and basic science information indicating the effect of the therapy on a model of AD would combine to make a convincing case for disease modification.
Other recent data points are consistent with these case studies.
This hypothesis seems consistent with our case.
For each brain isolate, the RIII mice were the first line to die of disease, consistent with previous transmissions from vCJD cases in the United Kingdom.
As a small but consistent number of salmonella cases began popping up on the radar of disease control monitors in the 1970s and '80s, the state stepped up testing of Stueve's certified raw milk.
