Nevertheless, we found that maternal smoking during pregnancy increased the risk of wheezing, an observation consistent with the deleterious effect of in utero exposure to tobacco smoke.
Homozygous carriers of the minor allele had lower CAMKIV protein expression and were under-represented among LLI's, consistent with a deleterious effect of this allele on longevity.
Consistent with a deleterious role, overexpression of MCP-1 in the brain exacerbates ischemic injury and correlates with inflammatory cell recruitment.
11 Consistent with these deleterious effects, antagonism of the TNF-α receptor has been demonstrated to improve endothelium-dependent vasodilatation in a variety of clinical settings such as congestive cardiac failure, 12 acute systemic vasculitis 13 and rheumatoid arthritis.
This result is consistent with the deleterious effect of abiotic stress on photosynthesis (Chaves et al., 2009) and shows the consequences of that effect on the expression of genes involved in the metabolic processes dependent on photosynthetic products.
Consistent with the deleterious effects of PSA knockdown and inhibition, we found that PSA overexpression (Supplementary Material, Fig. S2A) decreased the frequency of expanded huntingtin exon 1 GFP aggregates and the associated cell death in neuroblastoma cells (Fig. 2A).
Our results both in vivo and in vitro in cultured cardiomyocytes are consistent with a deleterious effect of imatinib on the heart that is dose, time, and age dependent.
These findings are consistent with a deleterious effect of smoking on mitochondrial biogenesis, which potentially could further exacerbate the pre-existing LHON-induced complex I defect in retinal ganglion cells, precipitating the onset of optic nerve dysfunction.
Whereas such atrophy has been associated with antiamyloid immunotherapy and could be related to reduction in inflammation or other effects of amyloid removal, the present data link atrophy to an adverse effect on cognition consistent with a deleterious pharmacological effect on the disease process.
Consistent with the deleterious effect of individual T alleles, the TA and GT haplotypes are present on some ISY elements but completely absent from ISX, that is, we find the two T mutations to be in perfect linkage disequilibrium among ISX elements but not ISY.
