19, 25 In the current absence of consistent clinical trials in subjects with more severe rash, patients are advised to use mild skin care and photoprotection.
In any case, we believe that evidence for the routine use of DrotAA should be based on consistent clinical trials and should not depend on the use of a particular meta-analytic statistical model, particularly one that does not account for between-trial heterogeneity.
Consistent clinical trial data strongly suggest that regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) lowers the lifetime risk of developing CRC (Algra and Rothwell, 2012, Arber et al., 2006, Chan and Lippman, 2011, Chan et al., 2007, Rothwell et al., 2010).
This finding is consistent with clinical trials.
These findings are consistent with clinical trials and other quasi-experiments that have failed to show significant reductions in mortality directly attributable to mammography [ 32].
This is consistent with clinical trials of systemic therapies including pazopanib (22.9 months) [ 4], sunitinib (26.4 months) [ 3] and bevacizumab (23.3 months) [ 26].
Respondents to our survey felt that the incidence and mortality in ARDS is decreasing and this is consistent with clinical trials published by the ARDS network over the past decade [ 1].
Finally, we examined the combined metabolic outcome data to assess whether the study results were consistent with clinical trials using intensive insulin management, but not using electronic data capture.
This finding is consistent with clinical trials showing that changes in the system of care for chronic disease may influence the relationship between literacy and health outcomes [ 17, 18].
This finding was consistent with clinical trials of anti‐CD3 intervention in new‐onset type 1 diabetes, where large cumulative doses were required for maintaining beta‐cell function 61, 62 and where phase III trials using low doses failed to meet their primary endpoints.
The ARPEGGIO study showed that 20 mg rimonabant significantly reduced A1C levels and improved multiple cardiometabolic risk factors in patients with type 2 diabetes receiving various types of insulin monotherapy, consistent with clinical trials of rimonabant in other type 2 diabetes populations (8, 11).
