Many consistent alterations were identified, with 114/749 probesets altered in all six normal tissue samples, and 153/684 probesets altered in all ten of the cancer tissue samples.
These results are therefore consistent with altered norepinephrinergic regulation in cocaine addiction.
This study illustrates a very tight concordance between both methods with a significant difference that NRO appears to anticipate changes in gene expression at time points earlier than they appear in total RNA, consistent with altered transcriptional rates followed by changes in total RNA.
The authors also found evidence of epigenetic changes that were consistent with altered gene expression in the liver.
Consistent with altered immune status we find spontaneous development of ileitis with features that closely recapitulate those of CD pathology.
Consistent with altered mitochondrial function, Casp2 appears to regulate the activity of complex III, which may contribute to increased ROS production and oxidative stress observed in Casp2 −/− mice.
These observations are consistent with the altered glucose sensing and altered apoptosis of β-cells in βIRKO mice [4], [5], [6].
Measuring the relationship between hydration status and brain function is complicated by a lack of clear and consistent methods in altering and measuring hydration status, particularly with respect to inducing dehydration.
When an existing time series is temporally extended, it is critical that previously generated change information remains consistent, thereby not altering reported change statistics or science outcomes based on that change information.
Consistent with this, altering Wts-Hpo activity in the eye can produce planar polarity phenotypes.
