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However, it has been difficult so far to generate strong and consistent adhesion blocking antibody responses against most single-domain VAR2CSA immunogens.
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The magnitude of the pull-in forces is consistent with adhesion arising from van der Waals (VDW) interactions, allowing us to estimate the ta-C/diamond Hamaker constant.
In contrast, platelets isolated from septic shock patients show a profound and consistent reduction in adhesion and aggregation response to a range of agonists [10-13] [10-13]e biochemical evidespitef increased platelet activity [14,15].
The results are consistent with the adhesion theory of friction in both an instantaneous and an average sense; even in the presence of substantial fluctuations in the normal contact force.
Furthermore, pRb knockout mice showed bone abnormalities consistent with osteoblast adhesion defects.
Immunofluorescence microscopy of both total and phospho-paxillin indicated intact and punctate staining consistent with focal adhesion formation in both wild-type and CXCL12-expressing HT29 cells in full growth medium (Figure 2E).
Consistent with the adhesion data, αv- and β3-integrin levels were significantly higher in β3-WT and β3-WT NRP1Δcyto ECs compared to their β3-HET counterparts.
FLO11 RNA levels in the S288c FLO11pr Sigma strain were consistent with the adhesion phenotypes; specifically, in S288c there was no significant difference in FLO11 RNA levels, regardless of the promoter or the presence of a tec1 Δ.
Laser photocoagulation and cryopexy produce less consistent and permanent adhesions on atrophic and pale areas [ 36].
We also noted the rapid formation of numerous GFP-paxillin puncta consistent with nascent adhesions after BDNF treatment (Additional file 5).
Consistent with the decreased adhesion complexes in Rac1shRNA infected cells, adhesion to fibronectin was reduced in these cells compared to control cells (Fig. 2B).
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