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We observed consistency in the direction of TRD with an overrepresentation of CTN 42 alleles in all but 2 of the 69 individual significant tests (Table S2).
In the AWHS, the replication study sample, the correlation between global DNA methylation and global DNA hydroxymethylation was positive, supporting consistency in the direction of the association in a human population with a different risk profile.
Due to the consistency in the direction of the effects, this might be considered a stronger case for replication.
One of our criteria for declaring successful transfer was consistency in the direction of effect size estimates [26].
There is little consistency in the direction of the difference.
The association for the GEC on the BRIEF also reflects the consistency in the direction of association on that instrument.
This consistency in the direction of the association between selective constraint and pathway position across the vertebrate phylogeny is not compatible with a random distribution of selective constraint levels along the IT pathway.
Therefore, for two hubs detected from two datasets separately, we additionally tested the consistency of the directions of their correlations with the shared neighbours across the datasets by the Bernoulli distribution model (see Methods).
Concordance measures the consistency of the directions between the observed state changes (corresponding to the pairwise differentially expressed genes) and the expected direction captured in the hypothesis model.
The "concordance" measures the consistency of the directions between the observed state changes and the expected direction from the hypothesis model.
In general, the enrichment coefficients positively correlate with consistency scores, decreasing in the direction from Tier 1 (highest consistency) to Tier 3 (lowest consistency).
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