A3309 led to significant improvements in other constipation-associated symptoms (stool consistency, straining, and bloating).
Patients also reported an improvement of stool consistency, straining, and abdominal bloating symptoms.
94 Clinical trials have demonstrated the efficacy of linaclotide in CC in improving stool consistency, straining, abdominal discomfort, bloating, global assessments, and quality of life.
Elobixibat also significantly relieved constipation-related symptoms such as stool consistency, straining on evacuation and abdominal bloating, according to the claims of several patients.
Plecanatide 3 mg was more effective than placebo on improving number of CSBM/week, stool consistency, straining and QOL score [ 94].
Linaclotide also proved effective in improving secondary endpoints, such as stool consistency, straining, abdominal discomfort, bloating, global assessments and quality of life.
38 In several multi-center RCTs, lubiprostone, when compared to placebo, has consistently shown to increase complete spontaneous bowel movements per week, as well as improved stool consistency, straining, constipation severity and patient-reported treatment effectiveness.
2, 34 In the lubiprostone group, a significant increase of SBMs/week was seen starting after the first week of treatment, along with improvement in stool consistency, straining, and constipation severity that was maintained throughout the 4 weeks.
