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Consistency of pathway annotation was evaluated by comparing the number of pathways for each species to the logarithm of its number of ORFs.
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From the analyses above, we realize the lack of comprehensiveness and consistency of different pathway databases at both the database level and the pathway level.
Within the genders however, the consistency of directional pathway regulation was almost complete, i.e. only one multi-diet regulated pathway was non-uniformly regulated in males (Shh) or females (intrinsic).
On the other hand, O may also be used to verify the consistency of biological pathway data (task ), and we can evaluate O with respect to.
We analyzed the consistency of individual pathways in order to determine whether a connectivity profile exists.
We further examined the consistency of the pathways detected by GIENA across three datasets.
Keeping in mind that mRNA levels may not be affected by those miRNAs that regulate translation efficiency, and that the levels of miRNA need not always result in mRNA level changes, this observation on the consistency of affected pathways is highly significant.
The consistency of the derived pathway networks with the prior model pathway information was evaluated as follows: given an edge in the derived network we assigned it a binary weight (1,-1) depending on whether the correlation between the two genes is positive (1) or negative (-1).
Likewise, there has been little quantitative data on the weight consistency of any given pathway.
The core assumption of their model was that because the consistency of a metabolic pathway is usually the result of the action of several genes, physical proximity is strongly correlated with clustering of cooperative functions.
The evaluation of pathway consistency and activity scores was also an approach used in [ 8].
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