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Additionally it tests for consistency of parameters in order to confer the estimation a robustness with respect to errors in the data.
The principal criteria are statistical adequacy of the model when compared with experiments, consistency of bed-independent parameters when estimated from bed response, and consistency of parameters of dispersion with respect to variations in the Schmidt group and Reynolds number.
Whittle's solution to the problem of estimating the parameters and the proof of consistency of parameters of the above sine wave used arguments which are not mathematically rigorous.
In his proof of consistency of parameters, he used the following O p result: max 0 ≤ ω ≤ π | ∑ t = 1 n Y t e i ω t | = O p ( n 3 4 ), where { Y t } is a linear process.
DisMod II [ 29], a software application provided by WHO, was employed to check internal consistency of parameters estimated.
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This study used the binary logit model due to consistency of parameter estimation associated with the assumption that error term in the equation has a logistic distribution (Baker 2000; Ravallion 2001).
To assess convergence, the effective sample size values and consistency of parameter estimates were monitored using Tracer v1.5 (http://tree.bio.ed.ac.uk/software/tracer/).ac.uk/software/tracer/
Uniform priors with minimum and maximum values of 0 and 10 000 were likewise specified for M. Two independent runs based on random starting trees were performed to ensure convergence and consistency of parameter estimates.
Fitting models separately for pre- and post-progression utilities when including time to death yielded similar coefficients for pre-progression and post-progression - the consistency of parameter estimates and standard errors across models when including progression status (moving from Model 2 to Model 3) indicate low levels of multi-collinearity between progression status and time to death.
However, it is not kinetically reasonable to modify the rate parameters of single reactions, because this will violate consistency of rate parameters of kinetically similar reactions.
This model was subsequently tested across a range of drugs in humans, 61 identifying drug effect parameters for several anticancer agents and showing good consistency of system parameters across all drugs evaluated.
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