Zimba was selected by researchers of Stanford University and icddr-b for a three-month trial in the slums of Dhaka to study the accuracy and consistency of dosing (the dosers remained in use for a year).
The recent development of a single-use injection device for administration of the fixed s.c. dose may further enhance convenience and consistency of dosing, in addition to offering the potential for self-administration.
To evaluate differences between three new-generation nebulizers Pari LC Star (Pari Respiratory Equipment; Mississauga, ON, Canada), AeroEclipse (Trudell Medical International, London, ON, Canada), and Halolite (Medic-Aid Limited, West Sussex, UK in terms of rate and amount of expected deposition as well as the consistency of the doses delivered.
The consistency of toxic doses across species when normalised to body surface area reflects the general relationship between surface area and a number of physiological processes which together determine drug clearance, as alluded to above.
The results of calculation and measurements have revealed good consistency of gamma dose and fast neutron 2D distributions obtained with gel dosimeters in form of layers.
This approach enables assessing the consistency of the dose-response relationship.
This is evidenced by the oxygen debt/probability of death curves for the animals, and by the consistency of lethal dose (LD 25,50 points for base deficit across all three species.
The authors concluded, "From a weight-of-evidence point of view, the hypothesized mode of action for formaldehyde-induced nasal tumors satisfies several criteria, including consistency, concordance of dose-response relationships across all key events, and biological plausibility and coherence of the database.
Examining the consistency of the allele doses inferred between the parents and progeny may be helpful, as long as the alleles have similar amplification efficiencies.
The objectives of this study were to (1) establish a human dosimetry profile of [11C]erlotinib and (2) assess the consistency of calculated equivalent dose across species using the same dosimetry model.
