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As biophysical chemists, our approach consisted of modifying the surroundings of the receptor, a common but complex method used in the biophysical community.
One consisted of modifying the ligation conditions, in particular the temperature, so as to minimize ligation of ends that are not perfectly complementary.
The second approach consisted of modifying the sequence joining modules 2 to and 3 (which is involved in inappropriate ligation to module 8): the sequence was changed from agtg to agtc (a silent substitution) to prevent inappropriate ligation to module 8.
Training consisted of modifying the domain lexicon in conjunction with the clinical expert and modifying the pattern dictionaries to account for errors involving contextual discrimination, including temporal discrimination, finding validation and contextual inference as described by Chapman et al. [ 14].
An example of item modification consisted of modifying the conceptual definition of the environment from a continuum (using the WC in the home, neighborhood, town) to a dichotomous definition (Q5/Q6, inside/outside home) to better reflect the vocabulary commonly used by end-users.
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Dinner consisted of modified lunch leftovers, unless it was lunch all over again, plus a cup of prune-based bowel-movement potion.
Treatment (information available for 524 patients) consisted of modified radical mastectomy in 320 cases (61%) or breast-conserving surgery plus locoregional radiotherapy in 204 cases (39%).
The supports consisted of modified ultra-stable-Y zeolite (MTZ) and an Al2O3 binder.
We present a simple approach for the fabrication of a full-thickness super-hydrophobic composite coating consisted of modified TiO2 nanoparticles and polysiloxane resin.
Iron-buffered medium consisted of modified synthetic complete medium to which MES (50 mmol/L 2- N-morpholino)ethanesulfonic acid, pH 6.1) buffer and iron chelator (1 mmol/L ferrozine) were added.
Perfusate consisted of modified Krebs-Ringer bicarbonate buffer containing 3% dextran (Sigma), 0.2% BSA (Sigma) plus 3 mM or 16.7 mM glucose gassed with 95% O2/5% CO2 and was kept at 37°C with heating units.
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