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Another set of active TF-gene pairs was selected by network inference, by considering the gene expression signatures for those periods between GK and Wistar-Kyoto (WKY) rats.
However, when considering the gene expression values themselves stratified by ER status, there was good agreement between our data set and that of the TRANSBIG study (Additional file 4: Figure S2 and Additional file 5: Figure S3).
We further investigated the effect of the transcriptional response by comparing the predicted metabolic response of untreated cultures while considering the gene expression levels of the untreated or the treated cultures (i.e., simulations without gene expression data vs. simulations with gene expression data).
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Additionally, we considered the gene expression in the context of chromosomal aberration.
For this purpose, we consider the gene expression response of steady-state yeast to pulses of glucose described in [ 28].
We considered the gene expression dataset GSE3494 treated in Miller et al. (2005) along with all available additional information.
For each patient, we considered the gene expression measurments of 51,852 transcripts (obtained using Aymetrix HU133 Plus 2.0; Aymetrix, Santa Clara, CA, USA) located on the autosomal chromosomes.
For that type of error, it may be useful to consider the gene expression bar code developed by Zilliox and Irizarry (2007).
If we consider the gene expression profile at 6 hours after inoculation (Additional File 2), we first notice the rapid increase of motif candidates that passed the expression significance filter.
The Modk-prototypes data analysis strategy was a multi-step process that considered the gene expression, clinical, and disease indicator covariates simultaneously in a meaningful disease context [ 12, 44].
As another example, to support a clinician in his treatment of a patient with breast cancer, an electronic health record (EHR) system could consider the gene expression profile of the patient's cancer biopsy and provide an individually-tailored prediction of how the patient is likely to respond to various therapeutic options [ 9].
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