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In the cross-validation tests described below, we predict for each non-localized enzyme either one or two compartments (based on the actual number of compartments the reaction is known to be localized to), by considering the compartments achieving the highest localization scores.
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In the test strategy, we consider the compartments: water, sediment and soil.
Unless you do something drastic to your methods (e.g., include a scoring scheme for quality of interaction, consider the compartments of the proteins and whether they can interact actually under TB infection or look meticulously at the biological function) this will stay so.
By providing both, the hollow brick cylinders are therefore expected to contribute to the attractiveness of a territory, and we consider the compartment with the larger brick structure to represent a territory superior in quality to the compartment with the smaller brick structure.
Although this correlation did not reach significance, when considering the separate compartments, we observed significantly higher expression of Snail1 in the tumour centre of small tumours (p=0.048, Figure 4B).
Considering the epithelial compartment of the primary tumour site only, none of the TIL subsets or macrophages had significant prognostic impact on NED-survival.
When considering the egg yolk compartment alone, 316 distinct gene products have been identified, by proteomics.
Predicted Cmax values considering the central venous compartment can over-predict the observed values up to 10-fold whereas the new sampling site predictions were within 2-fold of observed values.
The association between the presence of HLA DRB1*04 and the positivity for Pg DNA was confirmed also when considering the whole articular compartment (synovial fluid and synovial tissue) (joint Pg positivity: 55.6% in HLA DRB1*04 positive patients vs. 17.6% in HLA DRB1*04 negative patients, P = 0.03).
Examples of needs and challenges in tier 1 and tier 2 testing are presented in the following chapters and the test strategy considers the environmental compartments water, sediment, and soil.
Considering the number of affected compartments, patients with lesions in more than one compartment showed higher and statistically significant improvements in IKDC and in all the KOOS subscales (except for sport) compared to patients with lesions only in one compartment.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com