Sentence examples for considering that activation of from inspiring English sources

Considering that activation of the Wnt/β-catenin pathway results in the increased migration of numerous cell types in a variety of pathophysiological contexts, inhibition of GSK-3 leading to activation of β-catenin was speculated to stimulate astrocyte migration.

Zhou J et al(133) emphasize that considering that activation of HIF-1 provokes pro-survival as well as pro-death decisions under hypoxia, it will be crucial to understand decision making processes in regulating cell death, adaptation and chemoresistance.

Considering that activation of EGFR-MAPK signaling induces p27(Kip1) degradation, and p27(Kip1 -deficient mice develop corticotropinoma, we speculate that through activating EGFR signaling USP8 mutation accelerates p27(Kip1 -deficienton, representing an imicetant molecular mechanism undevelopg Acorticotropinomaion.

Considering that activation of PKC has been associated with increased expression of PLIN2 in macrophages [ 43], it is possible to suggest that in the present experimental conditions, PKC signaling pathway is important to MT-II-induced up-regulation of PLIN2, and thus to the increased formation of LDs.

Considering that activation of specific cholinergic pathways can inhibit pro-inflammatory cytokine synthesis and protect against endo-toxemia and ischemia-reperfusion injury [ 20], it is tempting to speculate that inhibition of these pathways, whether exogenous or endogenous, might contribute not only to CD but also to other outcomes of critical illness.

However, this does not compromise the therapeutic importance of blocking the AKT/mTOR pathway in this disease considering that activation of AKT/mTOR leads to resistance to chemo-reagents [ 38] and glucocorticoids [ 39] which constitute the first choice for the treatment of lymphoid malignancies including ALCL.

The physiological significance, however, is unclear when considering that the activation of AS160, which is downstream of Aktser473, was activated rather than suppressed by GH.

Considering that the activation of the canonical pathway of NF- κB has been implicated in the induction of pro-tumorigenic mediators, we determined the production of angiogenic factors such as MMP-9, VEGF-A and IL-8 by LPS-stimulated Mo/Ma co-cultured with TIS-T lymphocytes.

Therefore, considering that the activation of Nrf2 results in antioxidant defense response, bleomycin-induced lung injury can be used to evaluate the therapeutic effects of Nrf2 activators, We first evaluated the conditions (dose and injection frequency) that result in the activation of the Nrf2-dependent response in the lung of mice.

In this respect, the property whereby macroH2A1.1 binds with very tight affinity with OAADPR produced by SIRT1 is intriguing, considering that the activation of these enzymes is considered protective against NAFLD favouring a overall healthy aging [ 38], and is under scrutiny for drug design [ 39, 40].

Considering that transient activation of FUS3 post-embryonically increases ABA levels and that ML1 FUS3-GFP seeds are hypersensitive to ABA even at the optiML1 FUS3-GFPure of 21°C [ 17], we conclude that seeds overexpressing FUS3 are hypersensitive to high temperABArevend induces thermoinhibition through de novo attheatioptimalBA biosyntemperature