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Similar findings were observed at sensitivity analyses considering progression to micro- or macroalbuminuria in patients with persistent hyperfiltration as compared with those who had their hyperfiltration at inclusion ameliorated at month 6 (data not shown).
When considering progression events occurring during treatment and after treatment discontinuation, rates of freedom from progression to AP/BC remain statistically higher in the nilotinib-treated patients (96.3 and 97.8 % for nilotinib versus 92.1 % imatinib).
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For cytostatic agents or when the response assessment is difficult, adaptations to phase II designs may allow a better assessment of therapeutic activity: first by using the progression-free survival rate (PFSR) as primary end-point instead of the response rate, and second by considering progression-free survival (PFS) risk groups based on a prognostic index (PI).
Additional investigations regarding the role of PVE correction in tumour response assessment by considering progression-free survival or overall survival as end-points are still needed.
So far, we have only consider progression of neural encoding within 1 s snapshots, providing a limited view of fast adaptation dynamics.
The appearance of one or more new lesions was also considered progression.
For patients with measurable disease, a PSA increase in the absence of measurable disease progression was not considered progression.
Third, in this study we have only considered progression of the overall disease burden; modelling of progression in individually affected systems should provide useful understanding to clinicians with regard to patient care.
In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of a t least 5 mm (Note: The appearance of one or more new lesions is also considered progression).
In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm (Note: The appearance of one or more new lesions is also considered progression).
The model did not consider progression from asymptomatic carriage to disease; only a minor proportion of the carriers develop clinical symptoms, and it is believed that the spread of pneumococci primarily occurs via asymptomatic carriers.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com